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Gangliosides

We provide MS-based lipid analysis of gangliosides in a variety of sample types and deliver results in as little as two weeks.
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Details

Sphingolipids
Lipid Category
Gangliosides
Lipid Group

About the structure and biological function of Gangliosides

Structure. Gangliosides belong to the sphingolipids. Their structure consists of a ceramide backbone linked to an acidic oligosaccharide “head” group. The head group contains sialic acid sugars, their number is reflected in the name of ganglioside lipid classes: e.g. GT contains three sialic acids. The ceramide backbone of gangliosides contains a hydrocarbon chain termed long-chain base; one fatty acid is linked to the ceramide.

Function. Gangliosides are common to all animals but neither plants nor fungi. Their among lipids extraordinary physical properties make them essential components of cell membranes, where they support the formation of lipid rafts and caveolae, subdomains of the plasma membrane. Gangliosides are crucial in neuronal function and brain development, and can amount to 6% of the weight of lipids from the brain.

Monosialogangliosides (GM) are the most prominent gangliosides and influence neuronal functions through interaction with membrane receptors. Among the trisialogangliosides (GT), the GT1 gangliosides bind to myelin, the insulating layer that wraps around nerves, and thus connects it with the neuron. The GD3 gangliosides belong to the disialogangliosides (GD) and are critical to apoptosis, programmed cell death. Generally, ganglioside accumulation is linked to devastating diseases.

Gangliosides lipidomics analysis with Lipotype

Covered classes 11
Approach untargeted
Method mass spectrometry
Device Q Exactive Orbitrap (280.000 Res)
Quantification yes
Delivery time 2-4 weeks
Lipidomics data pmol & mol%

CORE STRUCTURE
Gangliosides

General molecular structure of the lipid group gangliosides.

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Lipid Navigator

Categories

Fatty Acyls Glycerolipids Phospholipids Sphingolipids Sterol Lipids Prenol Lipids

Groups

Fatty Acids Fatty Esters Fatty Amides Octadecanoids Eicosanoids Docosanoids Glycerol Esters Ester Phospholipids Ether Phospholipids Diphospha­tidyl­glycerols CDP-Glycerols Sphingoid Bases Ceramide Lipids Cerebrosides Diglycosyl­ceramides Phospho­sphingolipids Gangliosides Globosides Sulfoglyco­sphingolipids Cholesterol Lipids Ergosterol Lipids Isoprenoids Quinones

Classes

FFA LiFA SCFA MCFA LCFA SFA UFA WE CAR NAE oxiOME oxiODE Pgd LT TX LX IsoP oxiETrE oxiETE oxiEPE MaR RvD PD oxiDPA oxiDHA TAG DAG MAG PA PC PE PG PI PS LPA LPC LPE LPG LPI LPS BMP PC O- PE O- LPC O- LPE O- CL CDP-DAG Sph dhSph SphP dhSphP GlcSph GalSph Cer CerP dhCer doxCer EOdS EOS EOP EOH NdS NS NP NH AdS AS AP AH HexCer GlcCer GalCer DiHexCer LacCer SM CerPE IPC MIPC M(IP)2C GM1 GM2 GM3 GM4 GD1 GD2 GD3 GT1 GT2 GT3 GQ1 Gb3 Gb4 Sulf Chol CE Erg EE Sqe oxiSqe UQ
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