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Lactosylceramide

We provide MS-based lipid analysis of LacCer sphingolipids in a variety of sample types and deliver results in six or less weeks.

Details

Sphingolipids
Lipid Category
Lactosylceramide
Lipid Class

About the structure and biological function of LacCer

Structure. Lactosylceramides (cytolipin H, or LacCer) belong to the group of diglycosylceramides within the sphingolipids. Their structure consists of a ceramide backbone linked to a lactose molecule. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. Lactosylceramides serve an important role as key intermediates in the biosynthesis of more complex glycosylated sphingolipids. LacCer is particularly enriched in lipid rafts, subdomains of the plasma membrane, where it is assessed to assist in stabilizing the lipid raft and activating receptors. Lactosylceramides may bind to many species of pathogenic bacteria, and thus acts as a pattern recognition receptor. Further, LacCer is linked to initiating apoptosis and harmful accumulation of LacCer occurs in Fabry’s disease.

LacCer lipidomics analysis with
Lipotype

Structural detailsmolecular species
Variants identified > 10
Approachtargeted
Methodmass spectrometry
DeviceAgilent 1290 HPLC + 6495 Triplequad
Quantificationyes
Delivery time6 weeks
Lipidomics datapmol & mol%
Figuresincluded

EXAMPLE STRUCTURE
LacCer

An example for the molecular structure of lactosylceramide, specifically LacCer(d18:1/16:0).

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