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Cholesteryl Ester

We provide MS-based lipid analysis of CE sterol lipids in a variety of sample types and deliver results in as little as two weeks.

Details

Sterol Lipids
Lipid Category

About the structure and biological function of CE

Structure. Cholesteryl esters (cholesterol esters, or CE) belong to the group of cholesterol lipids within the sterol lipids. Their structure consists of cholesterol where an ester bond is formed between the hydroxyl group of the steroid structure and a fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Cholesteryl esters function as a transport form of cholesterol in blood plasma and in cells in lipid droplets. They serve as  storage containers  to  buffer excess cholesterol. They also serve as pool for cholesterol, for example for hormone synthesis in the adrenal glands, but also for free fatty acids. Cholesteryl esters accumulate in fatty lesions of atherosclerotic plaques. Further, cholesterol is inefficiently converted to cholesteryl esters in the blood of cardiovascular disease patients.

CE lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 50
Approachuntargeted
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, EOdS, EOS, EOP, EOH, NdS, NS, NP, NH, AdS, AS, AP, AH, Chol, CE

2Blood Basic includes:
TAG, DAG, PC, PE, PI, LPC, LPE, PC O-, PE O-, Cer, SM, Chol, CE

3Cells Basic includes:
TAG, DAG, PA, PC, PE, PG, PI, PS, SM, CE

EXAMPLE STRUCTURE
CE

An example for the molecular structure of cholesteryl esters, specifically CE 16:2;0.

EXAMPLE
CE 16:4;0

An example for the molecular structure of cholesteryl esters, specifically CE 16:4;0.

ABOUT LIPOTYPE

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

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    Aldeyra Therapeutics
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    Friedrich Miescher Institute
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    KU Leuven
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    DSM Skin Biology
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    Yale University
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    DIfE
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    University of Alberta
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    University of Virginia
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    University College London
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