Home   Sphingolipids   Ceramide Lipids   AH 

Alpha-hydroxy-6-hydroxysphingosine

We provide MS-based lipid analysis of AH ceramides in a variety of sample types and deliver results in as little as three weeks.

About the structure and biological function of AH

Structure. Alpha-hydroxy-fatty acid [A] 6-hydroxy-sphingosine [H] ceramides (CER[AH], or AH) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base, specifically 6-hydroxy-sphingosine, and a fatty acid, which is an α-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. The biological roles of alpha-hydroxy-6-hydroxy-sphingosines are tightly linked to skin health where they fulfill structural and signaling purposes. AH ceramides are involved in the formation of the epidermal barrier to protect against the environment and prevent trans-epidermal water loss. They are critical for barrier homeostasis. Aberrations of skin ceramide levels can contribute or lead to skin conditions. Further, AH ceramides are increased in Albino African skin.

AH lipidomics analysis with
Lipotype

Structural detailssubspecies level
Variants identified > 250
Approachuntargeted
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, EOdS, EOS, EOP, EOH, NdS, NS, NP, NH, AdS, AS, AP, AH, Chol, CE

EXAMPLE STRUCTURE
AH

An example for the molecular structure of alpha-hydroxy-6-hydroxy-sphingosines, specifically AH 18:1;3/28:0;1.

EXAMPLE
AH 18:1;3/28:0;1

An example for the molecular structure of alpha-hydroxy-6-hydroxy-sphingosines, specifically AH 18:1;3/28:0;1.

ABOUT LIPOTYPE

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

  • Thank you once again. The timing is extremely helpful to us.

    Susan Macdonald

    Aldeyra Therapeutics
  • Thank you very much. The results look fantastic!

    Stan Neufeld

    Friedrich Miescher Institute
  • The high-speed turn around when under revision really helped us!

    Rose E Goodchild

    KU Leuven
  • We highly appreciate the personal support and consultation.

    Rainer Voegeli

    DSM Skin Biology
  • We have been quite impressed. The results clearly indicate a difference.

    Pietro De Camilli

    Yale University
  • Cooperating with Lipotype, I enjoy custom packages and great support!

    Olga Ramich

    DIfE
  • After moving from one continent to another, I still prefer Lipotype!

    Julie Jacquemyn

    University of Alberta
  • Thank you very much for my new and shiny lipidomics data set!

    Ilya Levental

    University of Virginia
  • Lipotype Lipidomics is instrumental to our studies of membranes.

    Christopher J Stefan

    University College London
  • Lipotype is truly dedicated to supporting scientists in their research.

    Anonymous

    Anonymous

Request Analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Lipidomics? Please use the contact form below!