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Sphingoid Bases

We provide MS-based lipid analysis of sphingoid bases in a variety of sample types and deliver results in as little as six weeks.

Details

Sphingolipids
Lipid Category
Sphingoid Bases
Lipid Group

About the structure and biological function of Sphingoid Bases

Structure. Sphingoid bases belong to the sphingolipids. Their structure consists of an amino alcohol with a single hydrocarbon chain. The hydrocarbon chain may contain further double bonds, hydroxylations, and other groups such as phosphates or sugar molecules. The number and position of double bounds, hydroxylations, and further substitutes in the hydrocarbon chain defines the sphingoid base lipid class.

Function. Sphingoid bases can be found in all animals and plants and may be present in some fungi and bacteria. They serve as the defining structural unit of sphingolipids and thus as key intermediates and biosynthetic precursors to more complex sphingolipids. Yet free sphingoid bases are also bioactive.

Sphingosine is the most abundant sphingoid base in animals and together with sphingosine-1-phosphate plays an important role in intra- and inter-cellular signaling. Sphinganine is the biosynthetic precursor to sphingosine. In humans, the accumulation of glycosylated sphingoid bases such as glucosylsphingosine and galactosylsphingosine is linked to devastating diseases like Gaucher and Krabbe disease.

Sphingoid Bases lipidomics analysis with Lipotype

Covered classes 6
Approach targeted
Method mass spectrometry
Device Agilent 1290 HPLC + 6495 Triplequad
Quantification yes
Delivery time 6 weeks
Lipidomics data pmol & mol%

CORE STRUCTURE
Sphingoid Bases

General molecular structure of the lipid group sphingoid bases.

ABOUT LIPOTYPE

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    Friedrich Miescher Institute
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