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Eicosanoids

We provide MS-based lipid analysis of eicosanoids in a variety of sample types and deliver results in six or less weeks.
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Details

Fatty Acyls
Lipid Category
Eicosanoids
Lipid Group

About the structure and biological function of Eicosanoids

Structure. Eicosanoids belong to the fatty acyls. Their structure is based on eicosanoic acid, a twenty carbon atoms long hydrocarbon chain with a carboxyl group. Eicosanoids, docosanoids, octadecanoids, and further lipid groups are collectively termed oxylipins. Their hydrocarbon chain features oxygen-containing substituents, they are oxidized fatty acyls. Typically, eicosanoids contain multiple double bonds.

Function. Eicosanoids are found in eukaryotes such as animals, plants, and fungi, but rarely in prokaryotes. In cells, they are often in free form or linked to phospholipids to be released on demand. The composition of the hydrocarbon chain largely defines their biological function. Prostaglandins (PG), leukotrienes (LT), and lipoxins (LX) are probably the most prominent eicosanoids. They are well-known for their capacity to modify inflammatory responses.

Thromboxanes (TX) are noted for their role in platelet aggregation. Isoprostanes (IsoP) are the ‘gold standard’ for non-invasive measurement of oxidative stress. Oxidized eisocatrienoic (oxiETrE), eicosatetraenoic (oxiETE), and eicosapentaenoic acids (oxiPETE) serve diverse roles from being precursors to other eicosanoids and exerting signaling functions to modifying inflammation.

Eicosanoids lipidomics analysis with Lipotype

Covered classes 8
Approach targeted
Method mass spectrometry
Device Agilent 1290 HPLC + 6495 Triplequad
Quantification yes
Delivery time 6 weeks
Lipidomics data pmol & mol%

CORE STRUCTURE
Eicosanoids

General molecular structure of the lipid group eicosanoids.

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Lipid Navigator

Categories

Fatty Acyls Glycerolipids Phospholipids Sphingolipids Sterol Lipids Prenol Lipids

Groups

Fatty Acids Fatty Esters Fatty Amides Octadecanoids Eicosanoids Docosanoids Glycerol Esters Ester Phospholipids Ether Phospholipids Diphospha­tidyl­glycerols CDP-Glycerols Sphingoid Bases Ceramide Lipids Cerebrosides Diglycosyl­ceramides Phospho­sphingolipids Gangliosides Globosides Sulfoglyco­sphingolipids Cholesterol Lipids Ergosterol Lipids Isoprenoids Quinones

Classes

FFA LiFA SCFA MCFA LCFA SFA UFA WE CAR NAE oxiOME oxiODE Pgd LT TX LX IsoP oxiETrE oxiETE oxiEPE MaR RvD PD oxiDPA oxiDHA TAG DAG MAG PA PC PE PG PI PS LPA LPC LPE LPG LPI LPS BMP PC O- PE O- LPC O- LPE O- CL CDP-DAG Sph dhSph SphP dhSphP GlcSph GalSph Cer CerP dhCer doxCer EOdS EOS EOP EOH NdS NS NP NH AdS AS AP AH HexCer GlcCer GalCer DiHexCer LacCer SM CerPE IPC MIPC M(IP)2C GM1 GM2 GM3 GM4 GD1 GD2 GD3 GT1 GT2 GT3 GQ1 Gb3 Gb4 Sulf Chol CE Erg EE Sqe oxiSqe UQ
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