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Omega-hydroxy-sphingosine

We provide MS-based lipid analysis of EOS ceramides in a variety of sample types and deliver results in as little as three weeks.

Details

Sphingolipids
Lipid Category
Ceramide Lipids
Lipid Group

About the structure and biological function of EOS

Structure. Omega-hydroxy-fatty acid [EO] sphingosine [S] ceramides (CER[EOS], or EOS) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base, specifically sphingosine, and a fatty acid. The fatty acid is an ω-hydroxy fatty acid and “elongated” by a further fatty acid via an ester bond. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. The biological function of omega-hydroxy-sphingosines is tightly linked to skin health where they serve mainly structural roles. EOS ceramides are important to the lamellar phase of the epidermal barrier function which prevents trans-epidermal water loss but also protects against environmental factors. Skin ceramide imbalances can lead or contribute to the development of skin conditions. Decreased EOS levels are associated with atopic dermatitis, psoriasis, and dry skin.

EOS lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 10
Approachuntargeted
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, EOdS, EOS, EOP, EOH, NdS, NS, NP, NH, AdS, AS, AP, AH, Chol, CE

EXAMPLE STRUCTURE
EOS

An example for the molecular structure of omega-hydroxy-sphingosines, specifically EOS 72:3;2.

EXAMPLE
EOS 72:3;2

An example for the molecular structure of omega-hydroxy-sphingosines, specifically EOS 72:3;2.

ABOUT LIPOTYPE

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

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    Aldeyra Therapeutics
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    Friedrich Miescher Institute
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    KU Leuven
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    DSM Skin Biology
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    University of Alberta
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