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Lyso-phosphatidyl­choline

We provide MS-based lipid analysis of LPC phospholipids in a variety of sample types and deliver results in as little as two weeks.
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Details

Phospholipids
Lipid Category
Ester Phospholipids
Lipid Group
Lyso-phosphatidyl­choline
Lipid Class

About the structure and biological function of LPC

Structure. Lyso-phosphatidyl-cholines (lysolecithin, LysoPtdCho, LysoPC, or LPC) belong to the group of ester phospholipids within the phospholipids. Their structure consists of a glycerol backbone linked to a fatty acid and a phosphocholine molecule. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Lyso-phosphatidyl-cholines are potent signaling molecules and they have many functions related to inflammation and the immune system. They are suggested an important factor for neurodegeneration such as cognitive decline and dementia, and promote demyelination of neurons. Impaired levels of LPCs are also linked to cardiovascular disease and cancers. They have some functions in cell signaling. Further, LPC lipids have beneficial effects by activating macrophages.

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LPC lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 100
Approachuntargeted
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Blood Basic includes:
TAG, DAG, PC, PE, PI, LPC, LPE, PC O-, PE O-, Cer, SM, Chol, CE

2Cells Extended includes:
LPA, LPC, LPE, LPG, LPI, LPS, PC O-, PE O-, LPC O-, LPE O-, CL, Cer, HexCer

EXAMPLE STRUCTURE
LPC

An example for the molecular structure of lyso-phosphatidylcholine, specifically LPC 22:4;0.

EXAMPLE
LPC 16:0;0

An example for the molecular structure of lyso-phosphatidylcholine, specifically LPC 16:0;0.

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LPC
analysis?

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Categories

Fatty Acyls Glycerolipids Phospholipids Sphingolipids Sterol Lipids Prenol Lipids

Groups

Fatty Acids Fatty Esters Fatty Amides Octadecanoids Eicosanoids Docosanoids Glycerol Esters Ester Phospholipids Ether Phospholipids Diphospha­tidyl­glycerols CDP-Glycerols Sphingoid Bases Ceramide Lipids Cerebrosides Diglycosyl­ceramides Phospho­sphingolipids Gangliosides Globosides Sulfoglyco­sphingolipids Cholesterol Lipids Ergosterol Lipids Isoprenoids Quinones

Classes

FFA LiFA SCFA MCFA LCFA SFA UFA WE CAR NAE oxiOME oxiODE Pgd LT TX LX IsoP oxiETrE oxiETE oxiEPE MaR RvD PD oxiDPA oxiDHA TAG DAG MAG PA PC PE PG PI PS LPA LPC LPE LPG LPI LPS BMP PC O- PE O- LPC O- LPE O- CL CDP-DAG Sph dhSph SphP dhSphP GlcSph GalSph Cer CerP dhCer doxCer EOdS EOS EOP EOH NdS NS NP NH AdS AS AP AH HexCer GlcCer GalCer DiHexCer LacCer SM CerPE IPC MIPC M(IP)2C GM1 GM2 GM3 GM4 GD1 GD2 GD3 GT1 GT2 GT3 GQ1 Gb3 Gb4 Sulf Chol CE Erg EE Sqe oxiSqe UQ
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