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Sphingolipids

We provide MS-based lipid analysis of sphingolipids in a variety of sample types and deliver results in as little as two weeks.
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Details

Sphingolipids
Lipid Category

About the structure and biological function of Sphingolipids

Structure. Sphingolipids are one of the eight categories of lipids and contain tens of thousands of lipid species. All of these feature a similar molecular structure: they consist of a sphingoid base or long-chain base, an amino alcohol with a hydrocarbon chain. A variety of “head” groups can be linked to the sphingoid base, as well as a two fatty acids.

Function. Sphingolipids are present in all animals and plants and may be found in some fungi and bacteria. They are functional components of mainly cell membranes. However, great variability may apply regarding the types of findable sphingolipids in an organism. Ceramides are sphingolipids featuring a relatively simple structure. They serve as biosynthetic precursors to complex sphingolipids and are vital skin constituents.

Gangliosides, cerebrosides, and sulfoglycosphingolipids all feature some form of sugar head group and are crucial to the nervous system. Phosphosphingolipids are essential to lipid raft formation, functional subdomains of the cell membrane. The sphingolipid types globosides and diglycosylceramides serve important roles in the immune system.

Sphingolipids lipidomics analysis with Lipotype

Covered classes 46
Approach untargeted/targeted
Method mass spectrometry
Device Q Exactive Orbitrap (280.000 Res)
or
Agilent 1290 HPLC + 6495 Triplequad
Quantification yes
Delivery time 2-6 weeks
Lipidomics data pmol & mol%

CORE STRUCTURE
Sphingolipids

General molecular structure of the lipid category sphingolipids.

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Lipid Navigator

Categories

Fatty Acyls Glycerolipids Phospholipids Sphingolipids Sterol Lipids Prenol Lipids

Groups

Fatty Acids Fatty Esters Fatty Amides Octadecanoids Eicosanoids Docosanoids Glycerol Esters Ester Phospholipids Ether Phospholipids Diphospha­tidyl­glycerols CDP-Glycerols Sphingoid Bases Ceramide Lipids Cerebrosides Diglycosyl­ceramides Phospho­sphingolipids Gangliosides Globosides Sulfoglyco­sphingolipids Cholesterol Lipids Ergosterol Lipids Isoprenoids Quinones

Classes

FFA LiFA SCFA MCFA LCFA SFA UFA WE CAR NAE oxiOME oxiODE Pgd LT TX LX IsoP oxiETrE oxiETE oxiEPE MaR RvD PD oxiDPA oxiDHA TAG DAG MAG PA PC PE PG PI PS LPA LPC LPE LPG LPI LPS BMP PC O- PE O- LPC O- LPE O- CL CDP-DAG Sph dhSph SphP dhSphP GlcSph GalSph Cer CerP dhCer doxCer EOdS EOS EOP EOH NdS NS NP NH AdS AS AP AH HexCer GlcCer GalCer DiHexCer LacCer SM CerPE IPC MIPC M(IP)2C GM1 GM2 GM3 GM4 GD1 GD2 GD3 GT1 GT2 GT3 GQ1 Gb3 Gb4 Sulf Chol CE Erg EE Sqe oxiSqe UQ
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