About the structure and biological function of GlcCer
Structure. Glucosylceramides (GlcCer) belong to the group of cerebrosides within the sphingolipids. Their structure consists of a ceramide backbone linked to a glucose molecule. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.
Function. In humans, glucosylceramides are most abundant in skin to maintain the water permeability barrier by forming lamellar bodies in the stratum corneum. GlcCer also serve an important role as key intermediate in the biosynthesis of lactosylceramides and thus more complex glycosylated sphingolipids. Glucosylceramides have also been found to be required for intracellular membrane transport, cell proliferation and survival, and the immune system. Further, harmful accumulation of GlcCer occurs in Gaucher disease.
Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.
★★★★★
Thank you once again. The timing is extremely helpful to us.
Susan Macdonald
Aldeyra Therapeutics
Thank you very much. The results look fantastic!
Stan Neufeld
Friedrich Miescher Institute
The high-speed turn around when under revision really helped us!
Rose E Goodchild
KU Leuven
We highly appreciate the personal support and consultation.
Rainer Voegeli
DSM Skin Biology
We have been quite impressed. The results clearly indicate a difference.
Pietro De Camilli
Yale University
Cooperating with Lipotype, I enjoy custom packages and great support!
Olga Ramich
DIfE
After moving from one continent to another, I still prefer Lipotype!
Julie Jacquemyn
University of Alberta
Thank you very much for my new and shiny lipidomics data set!
Ilya Levental
University of Virginia
Lipotype Lipidomics is instrumental to our studies of membranes.
Christopher J Stefan
University College London
Lipotype is truly dedicated to supporting scientists in their research.
Anonymous
Anonymous
Request Analysis
You want to inquire lipid analysis for your project or ask questions about Lipotype Lipidomics? Please use the contact form below!
You are currently viewing a placeholder content from OpenStreetMap. To access the actual content, click the button below. Please note that doing so will share data with third-party providers.
