Lipid metabolic reprogramming is one hallmark of cancer. Lipid metabolism is regulated by numerous enzymes, many of which are targeted by several drugs on the market. Study by Dickinson and Silen characterized the lipid alterations in oral squamous cell carcinoma (OSCC) as a basis for understanding its lipid metabolism, aiming to identify potential therapeutic targets.

Lipid classes, species, and glycerophospholipid (GPL) fatty acid species were compared between paired tumor tissue and healthy oral tongue mucosa samples from 10 OSCC patients using Lipotype shotgun lipidomics technology setup.

This study demonstrated a shift in the lipid metabolism in these OSCC samples by characterizing the detailed lipidome landscape. Predominantly, cholesterol and GPL metabolism were altered, suggesting that interactions with sterol regulatory binding proteins may be involved. The fatty acid composition changes of the GPLs suggest increased de novo lipogenesis.

Discover more here: https://www.lipotype.com/lipidomics-resource-center/?q=squamous cell carcinoma

#lipidomics #lipidome #lipidMetabolism #massSpectrometry #HallmarksOfCancer